Description
Product Characteristics:
Adenine nucleotide translocator (ANT) and the voltage-dependent anion-selective channel proteins 1 and 2 (VDAC1 and VDAC2) are components of the permeability transition pore complex (PTPC) of the mitochondrial inner and outer membranes, respectively. Formation of PTPCs, the subsequent dissipation of mitochondrial inner membrane potential and release of cytochrome c through the outer mitochondrial membrane are critical events in the early stages of apoptosis. Bax, a proapoptotic protein, has been shown to act upon ANT to induce the dissipation of mitochondrial inner membrane potential. ANT1 has a role in the maintenance of mitochondrial DNA by catalyzing the exchange of ADP and ATP across the mitochondrial inner membrane.
Synonyms: ATP carrier protein 1, ADP ATP carrier protein heart/skeletal muscle isoform T1, ADP/ATP translocase 1, ADT1_HUMAN, ANT 1, ANT, ANT1, ATP carrier protein 2, ADP ATP carrier protein heart/skeletal muscle isoform T2, ADP/ATP translocase 2, ADT2_HUMAN, ANT 2, ANT, ATP carrier protein 3, ADP ATP carrier protein heart/skeletal muscle isoform T3, ADP/ATP translocase 3, ADT3_HUMAN, ANT3, ATP carrier protein 4, ADP ATP carrier protein heart/skeletal muscle isoform T4, ADP/ATP translocase 4, ADT4_HUMAN, ANT 4,ANT4.
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